Forty-two adult female cynomolgus macaques consuming a Western diet were characterized during an 18-month pretreatment phase and assigned to SSRI (sertraline hydrochloride 20 mg/kg, per os, once a day) or placebo balanced on pretreatment . CAA, analyzed by a 2 (depressed, nondepressed) × 2 (placebo, sertraline) × 3 (coronary arteries) analysis of covariance adjusted for pretreatment iliac atherosclerosis, was greater in depressed than in nondepressed monkeys ( = .040). The observed CAA extent in depressed monkeys treated with sertraline was 4.9 times higher than that in untreated depressed monkeys, and 6.5 times higher than that in nondepressed monkeys, on average. From the Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina. Address correspondence and reprint requests to Carol A. Shively, Ph D, Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1040. where to buy viagra in zimbabwe There is no guarantee that any side effects caused by Zoloft (sertraline) will go away if you stop taking it---or if you don't---and there is no time limit on how long side effects might stick around for. Antidepressants features thousands of potential side effects, and most side effects that emerge during the use of Zoloft tend to continue throughout treatment rather than fading away. There is also the concern of new or worsening side effects and withdrawal effects if Zoloft is discontinued. SSRIs cause withdrawal syndrome in the majority of patients, and even tapering off slowly will not necessarily prevent additional side effects from occurring. Sometimes missed doses, late doses, dose reductions, or medication switches can precipitate withdrawal syndrome even if someone is still taking Zoloft. 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Learn about Zoloft Sertraline Hcl may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. I have been on Zoloft for 3 months now and feel too like it has changed my life. I take 25 mg a day, and no longer get nervous in groups of people or dread social situations. I used to worry about EVERYTHING, but now I don't let things get me down. I can, however, feel some "twitching" (for lack of a better term) going on in my brain which makes me think about brain aneurysms. Iam weening off effexor right now and it is very hard because I was on a high dosage for a long time. I"m curious about the long term effects of Zoloft use on the brain. Hi, I only took zoloft for about 2 weeks and this was 7 years ago. I have been put on zoloft and taken off over the years and even though it did seem to work in keeping me active and focused I dealt with alot of side effects from the drug... 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