Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hydroxychloroquine with all of your drugs and health problems. Plaquenil pain medication Psoriasis and plaquenil Iupac name of chloroquine Severe side effects of plaquenil Jun 22, 2010 Overall I think the benefits of Plaquenil override any side effects and you hopefully can escape the nightmare known as predinisone. I also was offered methotrexate by my rheum but since I have only been on Plaquenil for 6 mos I will give it another 6mos before trying it as it scares me, the idea of taking the methotrexate. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. If they're coming and going more than likely it isn't the Plaquenil. From what I understand it is very rare for someone to have an allergic reaction to the Plaquenil and when they do that isn't how it shows up. Hopefull it's not the Plaquenil because this drug is really a very good drug for Lupus. For all uses of hydroxychloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Plaquenil photosensitivity Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Taking Plaquenil for Rheumatoid Arthritis Plaquenil side effects right awayCan you have a lupus flare while on plaquenilPlaquenil for rheumatoid arthritis reviewsWhat does the drug plaquenil do A doctor suspects a photosensitivity reaction when a rash appears only in areas exposed to sunlight. A close review of the person's medical history, skin symptoms, any diseases, drugs taken by mouth, or substances applied to the skin such as drugs or cosmetics may help a doctor pinpoint the cause of the photosensitivity reaction. Photosensitivity Reactions - Skin Disorders - Merck Manuals.. Plaqunil rash -. Will you have Photosensitivity reaction with Plaquenil.. Yes, my photosensitivity was the first thing to improve when I started treatment plaquenil. Plaquenil can improve photosensitivity. However imuran and other immunosuppressants, which I also take can worsen it. Both Sjogren's and Plaquenil can increase skin sensitivity to sunlight. There are other medications that can cause photosensitivity too. I never used to burn. I used to get a really deep tan. Nov 11, 2009 Plaquenil is generally agreed to reduce photosensitivity a little, so that it is an extra help, but not so much that other precautions can be relaxed. In a very few people it can cause a photosensitive reaction, by a different sort of mechanism, which cancels out the protective element.