While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "Hydrochloroquine (Plaquenil) has been a blessing for me. Target of chloroquine Hydroxychloroquine side effects kidney Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil belongs in a class of medications known as disease-modifying antirheumatic drugs DMARDs. Joint damage is linked to disability in rheumatoid arthritis and osteoarthritis. I was eager to begin treatment and stop the disease process. there is increased production of enzymes by the chondrocytes which contribute to cartilage destruction. There does. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage. I do occasionally experience dry eyes and a little scalp itch but asserting that it's caused by Hydrochloroquine would be anecdotal at best. It took about 5 weeks to take effect but my RA is basically a non factor now. Does plaquenil stop joint destruction in ra Rheumatoid Arthritis Progression Signs of Progressive RA, Joint Damage in Rheumatoid Arthritis and Can you have a lupus flare while on plaquenilChloroquine primaquine side effectsHydroxychloroquine during infection Rheumatoid Arthritis Support Group. Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. Plaquenil for fatigue and pain DailyStrength. RA and Hydroxychloroquine How Effective is it for.. Plaquenil and its affect on the immune system DailyStrength. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory pathways. Been taking plaquenil and arava for about a year. Just rediced plaquenil from one tablet twice a day to one tablet once a day. I also take Cimzia injections bi-weekly but that has only been for about 6 months. Jury is still out on that one. Plaquenil hydroxychloroquine "been taking Plaquenil for RA for around 6 months then about 3 weeks ago started having muscular pain, not as bad as the joint pain I used to have but enough to be concerned. muscle weakness, painful, as if I worked out for 2 hours praying it is a dosage problem"