Am very deflated as feel have come to stand still in my progression in fact have gone back somewhat (probably have done too much over the festive!! Am trying to be positive and keep telling myself I WILL get back to near as normal as possible. Can anyone assure me that YES the Lupus drug will kick in and I will be able to control my life again. Hydroxychloroquine overdose amount Hydroxychloroquine generic and brand names One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. That's a real common side effect of Lupus is unexplained rashes. If you've ever had an allergic reaction to a drug then this is the type of reaction you'd have if you were allergic to the Plaquenil; and they'd stay until the Plaquenil was out of your system. If they're coming and going more than likely it isn't the Plaquenil. Plaquenil and its affect on the immune system. My Rheumy seemed to blow off my concerns and said I have a crummy immune system anyway and it probably won't have any effect on the dysplasia --- Any one have any experience or info regarding pre-existing precancerous conditions and the effects of Plaquenil on the immune system. I see so. Wishing you all a good New Year and a Healthy one Kelpie21Took me a couple of weeks... I want to get back to work, exercise and enjoying normal day to day things such as being able to chopping onions, going for a drive and shopping!!!!! Does plaquenil have life long effects How long until Hydroxychloroquine takes effect - LUPUS UK, Plaqunil rash - Hydroxychloroquine pulmonary toxicity These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Plaquenil and its affect on the immune system DailyStrength. Will you have Withdrawal syndrome with Plaquenil - eHealthMe. Find user ratings and reviews for Plaquenil oral on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfaction. I have been on hydroxychloroquine. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.