Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine phosphate leth Hydroxychloroquine eyes Learn about the wide-ranging effects of hydroxychloroquine Plaquenil® in the treatment of lupus dosing, benefits, side effects and rare complications of this commonly prescribed medication. Drug spotlight on hydroxychloroquine Lupus Foundation of America Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. Up to half of patients treated with the arthritis drug hydroxychloroquine Plaquenil are prescribed more than the recommended maximum amount, according to new research. In separate studies, Canadian and U. S. researchers found that 30 to 50 percent of patients didn’t receive the dose outlined in treatment guidelines; a smaller percentage didn’t get recommended eye exams. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil eye chart RCOphth guideline Hydroxychloroquine and Chloroquine., Plaquenil hydroxychloroquine sulfate dosing, indications. Does plaquenil affect your sleep To be at risk of eye problems from Plaquenil you need to be on quite a high dose. The dose that you can safely tolerate depends on your size. If you weigh less than 30kg 66 lbs, then you may run in to problems on just one tablet a day. If you weigh less than 60kg around 9 ½ stone, 132 lbs then you may be at risk of eye problems on two tablets. Plaquenil & Your Eyes. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk.. Plaquenil Side Effects on Your Eyes and Vision. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Plaquenil and Your Eyes Here is an eye test that is easy for all of us to do online, without going to the doctor right away. Scroll down after you go to this site until a graph shows up with a dot in the center. Look at the dot with one eye at a time, and if the lines change, then you might need to see the doctor. Alot of the concerns are related to the problems caused by chloroquine, the predecesor to hydroxychloroquine Plaquenil. It was much more toxic to the retina and much more likely to cause permanent visual problems. Hydroxychloroquine, on the other hand, is much less toxic to the retina and there have been fewer reported eye problems.