Pharmacological treatment with chloroquine inhibits autophagy in vivo

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  1. AlexS New Member

    Pharmacological treatment with chloroquine inhibits autophagy in vivo


    Several cancer treatments stimulate the autophagic process and when autophagy is inhibited, cancer cells show an enhanced response to multiple treatments. These findings have nourished the theory that autophagy provides cancer cells with a survival advantage during stressful conditions, including exposure to therapeutics.

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    Inhibition of autophagy by chloroquine induces apoptosis. Fig. 2 CQ inhibits the autophagy process and induces. In vivo treatment with TAK-243 restricted the growth of xenografted DLBCL. Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms. The ratio of LC3-II to LC3-I was also upregulated by RS9 treatment at both 6 and 24 h after NaIO 3 treatment. Chloroquine co-treatment further upregulated the levels of these proteins Fig. 4 A, C. Notably, the autophagy substrate p62/SQSTM1 was transiently upregulated by RS9 treatment only at 6 h after NaIO 3 treatment Fig. 4 A, D.

    In this review we examine two approaches to modulate autophagy as complementary cancer treatment: inhibition and induction. Therefore, interference with the autophagic response can potentially enhance the efficacy of cancer therapy.

    Pharmacological treatment with chloroquine inhibits autophagy in vivo

    Dissecting pharmacological effects of chloroquine in., Inhibition of autophagy with bafilomycin and chloroquine.

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  6. Autophagy has been identified as a cellular process of bulk degradation of cytoplasmic components and its persistent activation is critically involved in the renal damage induced by ureteral obstruction. However, the role and underlying mechanisms of autophagy in hyperuricemic nephropathy HN remain unknown. In the present study, we observed that inhibition of autophagy by 3-methyladenine 3.

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    Autophagy is a catabolic process through which eukaryotic cells degrade disposable, ectopic or damaged cytoplasmic material. The inhibition or hyperactivation of autophagy has been linked to the. Treatment of such cells dependent on autophagy for survival with the drug chloroquine CQ results in brisk cell death. CQ is a lysosomotropic drug that raises intralysosomal pH 10 and impairs autophagic protein degradation 11. Nov 15, 2015 Indeed, preclinical studies have shown that the pharmacological inhibition of autophagy with agents including chloroquine, hydroxychloroquine, metformin, and desmethylclomipramine can enhance the cell-killing effect of cancer therapeutics, and a number of these agents are currently under investigation in clinical trials. However, many of these autophagy modulators are relatively nonspecific, and cytotoxicity in noncancerous tissues is still a concern.

     
  7. Minister Well-Known Member

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  8. AkaaaMA User

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  9. 3377 Well-Known Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version.

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  10. AmiGator New Member

    Plaquenil and dizziness? Updated I know it was the Plaquenil because I was not dizzy before I started it. It was like being on a boat all day and then getting off and still feeling like I was on the boat. Different doctors gave me different answers as to the cause. Anyway it did go away and after about 8 months the plaquenil took most of the joint pain away. Sue Ann

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