Some drugs fight inflammation and ease pain, while others help slow disease progression. If there's any comfort in having rheumatoid arthritis these days, it’s that there's a growing number of drugs to deal with its symptoms. Not only can some medications help manage the inflammation, pain, and symptoms of rheumatoid arthritis, but they can stop or slow the progression of the disease, too. Z 038 is this hydroxychloroquine Chloroquine and sun exposure Methotrexate is often used in combination with other DMARDs. Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. If a patient is resistant to initial DMARD treatment with an agent such as methotrexate, combination DMARD treatment may be used, adding one or more conventional DMARDs leflunomide, hydroxychloroquine, sulfasalazine or a newer biologic treatment to methotrexate. While, the disease-modifying anti-rheumatic drug DMARD methotrexate is the drug of choice for initial treatment of RA and many individuals respond well to monotherapy only using this one medication, others need a combination of DMARDs, including methotrexate and other conventional DMARDs, or methotrexate and selected biologics. Treatment guidelines from the American College of Rheumatology (ACR) state that early aggressive treatment is the best way to prevent irreversible joint damage and to maintain quality of life for people with rheumatoid arthritis. Traditionally, rheumatoid arthritis treatments have included a combination of DMARDs, or disease modifying anti-rheumatic drugs, that now include different forms of biologics and two other classes of medications: non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. Dmards plaquenil methotrexate Rheumatoid arthritis, monitoring of DMARDs - BPJ 17., Traditional Disease-Modifying Anti-Rheumatic Drugs DMARDs Does plaquenil cause cancerChloroquine diphosphate solubilityPlaquenil interaction with alcohol Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Treatments for Rheumatoid Arthritis. Combinations of conventional & biologic DMARDs. Methotrexate - Arthritis Foundation. Commonly used oral DMARDs include methotrexate, sulfasalazine, hydroxychloroquine, low-dose prednisone and a newer agent, leflunomide. Other less commonly used DMARDs include azathioprine, cyclosporin and sodium aurothiomalate intramuscular gold. Biological DMARDS, tumour necrosis factor TNF inhibitors, are discussed below. The most commonly used DMARD is methotrexate Trexall®, Rheumatrex®, Otrexup®, Resuvo®. Other DMARDs include sulfasalazine Azulfidine®, leflunomide Arava®, hydroxychloroquine Plaquenil®, Cyclosporine Neoral®, Sandimmune®, Azathioprine Imuran®, and Apremilast Otezla®. DMARDs are, then, an important clinical alternative. DMARDs Classification. DMARDs pharmacology is commonly classified as follows Synthetic DMARDs sDMARD Conventional synthetic csDMARD hydroxychloroquine, methotrexate; the traditional examples of DMARDs.