Please review the following URL and make sure that it is spelled correctly. Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Chloroquine for malaria prophylaxis dosing Hydroxychloroquine sun allergy Plaquenil and vascular system Any one have any experience or info regarding pre-existing precancerous conditions and the effects of Plaquenil on the immune system. I see so much info on the net where some says that Plaquenil has very mild effect on immune system except for eye issues --- Other info says it is an immunosuppressant. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. It may prevent joint damage and reduce the risk of long-term disability. It can decrease the pain and swelling of arthritis. Plaquenil immune system Does plaquenil cause shingles, does it suppress the immune., Taking Plaquenil for Rheumatoid Arthritis Kikuchi-fujimoto disease hydroxychloroquine as a treatmentChloroquine synthesis reactionChloroquine dormantPlaquenil vaginalAra patient information sheet hydroxychloroquine Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. This type of disease occurs when the body's immune system attacks its own healthy tissue. What Is Plaquenil? - American Academy of Ophthalmology. Hydroxychloroquine Plaquenil. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Several small and uncontrolled studies have examined the effects of chloroquine or hydroxychloroquine on immune activation. One study of 8 patients taking chloroquine but no concomitant antiretroviral therapy for 8 weeks reported a decrease from 8% to 5.5% in the percentage of memory CD8 cells expressing HLA-DR and CD38. There is evidence that hydroxychloroquine may interfere with communication between cells in the immune system. This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives.