Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Metabolism of chloroquine Hydroxychloroquine baseline eye exam Accidently took next days dose of hydroxychloroquine Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy. Nov 15, 2015 Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Gambogic acid GA and chloroquine CQ act synergistically against a pancreatic cancer xenograft tumor model. Xenograft tumor model was created with BxPC-3 cells in nude mice. a Xenograft tumors of four groups. b Tumor volume of four groups was measured every 3 days. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine and pancreatic cancer Malaria drug could be used to treat pancreatic cancer - Pancreatic., Chloroquine & Hydroxychloroquine supporting chemo. Macular scar tissue plaquenilPlaquenil drug reviewsHydroxychloroquine manufacturer couponsPlaquenil urticaria schnitzler syndrome Pancreatic cancer is notoriously treatment resistant. These tumors rely on lysosome-dependent recycling pathways to generate substrates for metabolism, which are inhibited by chloroquine CQ and its derivatives. However, clinical efficacy of CQ as a monotherapy or combined with standard-of-care regimens has been limited. Lysosome inhibition sensitizes pancreatic cancer to.. Gambogic acid induces autophagy and combines synergistically with.. Chloroquine targets pancreatic cancer stem cells via.. Mar 20, 2019 Pancreatic cancer cells rely on lysosome-dependent pathways, which are an essential component of autophagy, where cancer cells break down and recycle some of their own components for fuel. Any prior radiotherapy or combined radio-chemotherapy for pancreatic cancer if completed less than 12 months prior to study inclusion. Known hypersensitivity to trial drugs or hypersensitivity to any other component of the trial drugs. Known glucose-6-phosphate dehydrogenase deficiency. Concurrent use. Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with.