Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Chloroquine production process When is the best time to take hydroxychloroquine Aug 18, 2009 I thought that plaquenil was more processed by the kidneys than the liver and the problem you describe is what my gi doc calls "dumping" when the liver can't handle the med and acts like its poison and you get explosive diarrhea as your body tries to get rid of it. I have been on Plaquenil and can tell you my diarrhea started within days of starting the med. My doctor warned me that diarrhea and weight loss were side effects. I said, "Well, I am usually very constipated and could stand to lose 10 pounds so this could be a good thing." haha. I am NOT constipated any more but have not lost any weight either. I suspect plaquenil for giving me some episodic diarrhea. I am 100 mg dose and take it with my supper. Did they happen to anyone else and did it eventually stop with the diarrhea side effect? It helps so much with the fatigue and pain. I have a sensitive stomach and perhaps I shouldn't have eaten that salad for lunch yesterday. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Can plaquenil cause diarrhea Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil, diarrhea and weight loss? Hydroxychloroquine and lupus pregnancy I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. I understand these may go away. Is there anything I can. Stomach problems with Plaquenil • Johns Hopkins Arthritis Center. Plaquenil and diarrhea -. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Aug 26, 2016 I was getting diarrhea after staring plaquenil. My Gastro dr gave me VSL-3, its a probiotic. It is like a miracle drug to me. I haven't had diarrhea in a year. Maybe you can try that. It's over-the-counter. The pharamacist has t get it, it has to be refrigerated. I recently had to take an antibiotic which has a side effect, for my, of diarrhea. Doctors give unbiased, trusted information on whether Hydroxychloroquine can cause or treat Diarrhea Dr. Cattano on plaquenil and diarrhea Temporary GI disturbances are quite common with antibiotics, so a little patience with this understanding comes handy to get the intended benefit from the treatment.