At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Autofluorescence test for plaquenil toxicity Plaquenil as it affects the eyes symptoms Plaquenil can cause loss of appetite and I agree that losing weight at this rate and suffering diarrhea is not healthy and might mean you become ill nourished and dehydrated. I suggest lowering the dose, going back to the original, until your tum has settled down then very gradually increasing it to give your body the maximum chance to adjust. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil has been the one and only drug I've taken, but aside from weight gain, I was getting migraines that made me feel like I was dying, my vision was immediately affected blurry, photosensitive, my gums were bleeding, I was dizzy all the time and always has a terrible sore throat - not to mention the nightmares from Hell every night. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Average weight loss on plaquenil Plaquenil Hydroxychloroquine - Side Effects, Dosage., Plaquenil Oral Uses, Side Effects, Interactions. Hydroxychloroquine retin Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Here are 8 weight loss tips that you can ignore. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil and weight gain -. Hydroxychloroquine Side Effects Common, Severe, Long Term.. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules By the old standards, obese people, if dosed by their actual weight, could be overmedicated, Dr. Marmor said. If you’re short, the standard prescription of 200 mg of Plaquenil, twice daily, is too much, he said. The recommended dosage is no more than 6.5 mg/kg/day, using the standard known as “ideal weight,” which factors in height. Dr. Weight loss is a relatively unusual side-effect of plaquenil so I'd want to be very sure that that is what is causing the problem. I would certainly hesitate to lower the dose you are on without talking to your doc as 2x200mg is the usual dose for most people 6.5mgs per kilo ideal body weight or 3mgs per lb.