Surfactant protein c deficiency hydroxychloroquine

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    Surfactant protein c deficiency hydroxychloroquine


    The exact physiopathology of this disease is not known and there is no specific treatment for it. There is merely news from a few previous descriptions in the literature about the use of hydroxychloroquine for surfactant protein C deficiency with satisfactory results.

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    There is merely news from a few previous descriptions in the literature about the use of hydroxychloroquine for surfactant protein C deficiency with satisfactory results. Nogee LM, Brody AS, et al. Surfactant protein deficiency in familial interstitial lung disease. J Pediatr. 2001;1-92. 28. Rabach I, Poli F, Zennaro F, Germani C, Ventura A, Barbi E. Is treatment with hydroxychloroquine effective in surfactant protein C deficiency? Arch Bronconeumol. 2013;3-215. 29. Beers MF. Hydroxychloroquine and Surfactant Protein C Deficiency Article in New England Journal of Medicine 3522207-8 February 2005 with 222 Reads How we measure 'reads'

    These data seem to cast some doubt on the efficacy of hydroxychloroquine, and they suggest that the clinical improvement was simply the natural evolution of the disease. Two years after the treatment was withdrawn, the twins were evaluated once again: they presented no new infections, growth and general state were normal and chest CT showed a notable additional reduction in the interstitial pneumopathy.

    Surfactant protein c deficiency hydroxychloroquine

    Surfactant protein C - Wikipedia, Surfactant protein C dysfunction with new clinical insights.

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  3. Pulmonary Surfactant Metabolism Dysfunction 2. In a female infant with respiratory insufficiency due to surfactant metabolism dysfunction SMDP2; 610913 and surfactant protein C deficiency, Nogee et al. 2001 identified a heterozygous mutation in the SFTPC gene 178620.0001patient's affected mother also carried the mutation.

    • SURFACTANT, PULMONARY-ASSOCIATED PROTEIN C; SFTPC - OMIM.
    • Hydroxychloroquine and Surfactant Protein C Deficiency..
    • Surfactant Deficiency Causes & Reasons - Symptoma®.

    We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success. The exact physiopathology of this disease is not known and there is no specific treatment for it. The diagnosis of a surfactant protein C mutation c.545 GC.pGly182Arg was confirmed by genetic testing once available. Patient 1 had a family history of a maternal uncle dying of pneumonia at 6 months of age and a maternal grandfather dying of lung disease at 49 years of age, but neither one had genetic studies performed. Hydroxychloroquine and Surfactant Protein C Deficiency to the editor We wish to report initial success in treating a boy with surfactant protein C deficiency.

     
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