It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Maculopathy hydroxychloroquine Is hydroxychloroquine hepatotic Last week my doc added plaquenil to the mix. I have a pharmacist friend that says it can take up to a year to work, but once its kicks in it can be really good. I suggest you ask your rhuemie for additional help in the meantime. I have had RA going on 12 years, and originally way back when I ws given plaquenil alone and it did nothing. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. I take Nsaids for pain to get me through a work day when I am having a tough time. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Plaquenil time to work Ask the Expert Plaquenil and Sjögren’s, Plaquenil for fatigue and pain DailyStrength Does plaquenil have life long effects What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Plaquenil Uses, Dosage & Side Effects -. If you are pregnant or considering becoming pregnant, discuss Plaquenil with your doctors. Though Plaquenil is generally regarded as safe during pregnancy, it is recommended that effective birth control is used throughout the course of Plaquenil treatment and for up to six months after treatment is stopped. If you are taking hydroxychloroquine over a long duration, it is important to take eye exams every 6 to 12 months. 6 Do not take hydroxychloroquine if you experience vision symptoms, including problems seeing or reading, light sensitivity, blurred distance vision, or light flashes or streaks. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.