I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Chloroquine dose in rheumatoid arthritis Chloroquine resistance areas Lupus medication hydroxychloroquine Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. I have been on the plaquenil 200 mgm for about 4 months now. I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Noticed nothing different. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Additional doses of 6.5 mg/kg maximum dose 400 mg should be given at the following times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Prevention Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center, Let me tell you what weaning down from Plaquenil is like. Chloroquine user reviewsHydroxychloroquine tablets ip 400 mgDoes plaquenil relieve fibromyalgia or psoriatic arthritis The first dose of Plaquenil is usually taken one to two weeks before traveling to an area where malaria is prevalent. Doses are then continued for four weeks after exposure. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Rx Side Effects New Plaquenil Guidelines and More.. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. This site complies with the HONcode standard for trustworthy health information. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember.