I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Hydroxychloroquine and lung cancer Does chloroquine kill cyanobacteria Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Methotrexate–hydroxychloroquine combination therapy may cause lower disease activity in early RA than methotrexate monotherapy. Methotrexate monotherapy as first early RA treatment seems to lead to more treatment intensification. Methotrexate is a type of disease-modifying anti-rheumatic drug DMARD. It’s used to reduce activity of the immune system for people who have certain conditions. The immune system normally protects the body from infections or bacteria by causing inflammation to fight them. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Methotrexate and hydroxychloroquine Methotrexate vs. Plaquenil - Autoimmune diseases - Inspire, Effects of methotrexate and hydroxychloroquine combination. Plaquenil superamaHydroxychloroquine elimination Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine Uses, Dosage & Side Effects -. Methotrexate Side-effects, uses, time to work. Methotrexate and Plaquenil drug interactions - eHealthMe. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. We aimed to compare the efficacy of methotrexate and hydroxychloroquine on refractory lichen planopilaris. Methods In a randomized clinical trial, 29 patients were randomly allocated to receive either 15 mg methotrexate/week or 200 mg hydroxychloroquine twice a day for 6 months. Curcumin in turmeric may increase the therapeutic action of arthritis medications and protect from their side effects as well. Let’s examine the scientific details behind the safety of taking turmeric and curcumin with arthritis medications. 1. Curcumin may change drug absorption. Turmeric and curcumin are safe for consumption.