One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil and lupus Hydroxychloroquine pronunciation Can plaquenil cause diarrhea Chloroquine phosphate effects on fish Aug 01, 2009 A friend told me that the Plaquenil can cause problems with your eyes which is why I checked this board today. I have an appointment with my Rhuematolgist who put me on this medicine at the end of the month and I believe the dose is going to be increased should I tell him about my eye sight loss or call my eye doctor? A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11. Feb 19, 2020 Corticosteroids and salicylates may be used in conjunction with PLAQUENIL, and they can generally be decreased gradually in dosage or eliminated after a maintenance dose of PLAQUENIL has been achieved. HOW SUPPLIED. PLAQUENIL tablets are white, to off-white, film coated tablets imprinted “PLAQUENIL” on one face in black ink. Each tablet contains 200 mg hydroxychloroquine sulfate equivalent to 155 mg base. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Whats the dosage that causes plaquenil toxicity Hydroxychloroquine Side Effects, Dosage, Uses, and More, Hydroxychloroquine Plaquenil Toxicity and. Plaquenil is os junctionChloroquine psoriasis I normally post on the arthritis board, and due to toxicity of the Plaquenil after 2 years, I have had to discontinue it, since I failed the visual field testing. Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. Discontinued Plaquenil.other options?. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Advanced hydroxychloroquine toxicity presents as a bullseye maculopathy. Since retinal toxicity is usually irreversible, early detection of retinal toxicity and cessation of the offending agent is the best treatment. Corneal toxicity presents as an intraepithelial deposition of the drug into the cornea, which rarely affects vision. Dr. Fraunfelder “One of the main rules, but not a hard rule, is if it’s a drug toxicity, it usually is bilateral.” Dr. Fung “I’m always concerned that the prescribing doctors are not completely aware of the dose-related toxicity of chloroquine and hydroxychloroquine. So I always check and calculate the dose. Jan 03, 2020 Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg.