Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

Discussion in 'Generic & Brand Canadian Pharmacy' started by dekart0, 19-Mar-2020.

  1. OLEG-apx Guest

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Oct 04, 2002 Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a. We believe that our results, besides shedding light on the mechanism of chloroquine resistance in P. falciparum, have implications for the development of novel therapies against resistant malaria strains and demonstrate the usefulness of an approach combining systems biology strategies with structural bioinformatics and experimental data. Extrusion of chloroquine CQ from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter PfCRT is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ remain unknown.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

    Malaria Dissecting chloroquine resistance - ScienceDirect, On the mechanism of chloroquine resistance in Plasmodium.

  2. Hydroxychloroquine iris
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  5. During the past year, confirmed chloroquine-resistant infections have been described from specific areas in Zambia 3 and Sudan 4; previously, Kenya, Tanzania, Uganda, Madagascar, and the Comoros Islands were acknowledged to have transmission of chloroquine-resistant P. falciparum.

    • Update Chloroquine-Resistant Plasmodium falciparum -- Africa.
    • Plasmodium falciparum chloroquine resistance transporter..
    • Chloroquine mechanism of drug action and resistance in..

    Resistance to chloroquine, in the case of P. falciparum, is linked to mutations in the P. falciparum chloroquine resistance transporter pfcrt gene, which alters the transport and accumulation of the drug in the digestive vacuole DV of the parasite 7, 8. Resistance to chloroquine has, however, steadily spread since the 1960s from two foci, one in South America and one in South East Asia. Throughout the 1980s, chloroquine resistance spread through Africa, the global heartland of malaria mortality and morbidity, and there are very few effective and affordable drugs to take its place. Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, Milhous WK, Schlesinger PH. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance. Science. 1987 Nov 27; 238 48311283–1285. Krogstad DJ, Schlesinger PH. A perspective on antimalarial action effects of weak bases on Plasmodium falciparum. Biochem Pharmacol.

     
  6. mazzy Well-Known Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis RA and Your Eyes Complications Rheumatoid Arthritis. Plaquenil eye problems Mayo Clinic Connect
     
  7. iamagin XenForo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Side Effects of Aralen Chloroquine, Warnings, Uses Chloroquine treatment of ARPE-19 cells. - PubMed Central PMC Hydroxychloroquine - Wikipedia
     
  8. Marchell Guest

    Hydroxychloroquine and the immune system Hi everyone. It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much eg checking your white blood cell levels, so you shouldn't be completely vulnerable.

    Is Plaquenil a immunosuppressant drug ? Autoimmune.
     
  9. Darza User

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as.

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.