Chloroquine treatment of amoebic liver abscess

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  1. zymmaster Guest

    Chloroquine treatment of amoebic liver abscess


    After completion of treatment with tissue amebicides, administer luminal amebicides for eradication of the asymptomatic colonization state. Failure to use luminal agents can lead to relapse of infection in approximately 10% of patients.

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    Comparison of metronidazole and chloroquine for the treatment of amoebic liver abscess. A controlled trial. Cohen HG, Reynolds TB. Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An Eleven patients 9 male, 2 female with amoebic liver abscess were treated by the author in Bombay during a period of 2 years. E. histolytica was found in the stools in 2 cases. When once the diagnosis of liver abscess was established by aspiration of pus, treatment with chloroquine was instituted. Emetine was not given in any case. Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Chloroquine was given according to the standard protocol at Los Angeles County-University of Southern California Medical Center, which is 500 mg daily for 10 weeks, whereas metronidazole was given in a dose of.

    The details on tissue and luminal amebicidal agents are discussed in Medication. In general, metronidazole, tinidazole, emetine, and dehydroemetine are active in invaded tissues; chloroquine is active only in the liver; tetracycline acts on the bowel wall; and diloxanide furoate, paromomycin, and iodoquinol are luminal agents only.

    Chloroquine treatment of amoebic liver abscess

    Amebic Liver/Hepatic Abscesses Treatment & Management., Chloroquine in the Treatment of Amoebic Liver Abscess.

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  3. While emetine combined with emetine bismuth iodide is usually effective in the treatment of hepatic amoebiasis, there is a residue of cases of liver abscess in which these drugs fail to act. The author refers to the use of chloroquine in hepatic amoebiasis and suggests that it probably acts by concentration in the liver parenchyma for experimental observations on animals regarding relative.

    • The Treatment of Amoebic Liver Abscess with Chloroquine..
    • Comparison of Metronidazole and Chloroquine for the Treatment of..
    • Amebic liver abscess SpringerLink.

    Amebic liver abscess is the most frequent extraintestinal manifestation of Entamoeba histolytica infection. This infection is caused by the protozoa E histolytica, which enter the portal venous system from the colon. Alternative treatment of amebic liver abscess involves the use of emetin - 1 mg / kg per day once intramuscularly no more than 60 mg / day for 4-6 days chloroquine base - 600 mg per day for 2 days, then 300 mg for 2-3 weeks - simultaneously or immediately after the completion of the course of emetine. The second line drugs in treatment of amoebic liver abscess include emetine and chloroquine. Combination of more than one drug is not superior to use of single drug as there is no evidence at present of the superiority of combining two or more anti amoebic drugs. The treatment regimen for amoebic liver abscess should include use of luminal.

     
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