It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine generic name Does hydroxychloroquine thin the blood The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. According to results from the first clinical trial to systematically investigate the optimal administration of methotrexate in patients with active rheumatoid arthritis, published in the January 2008 issue of Arthritis & Rheumatism, methotrexate injection also referred to as subcutaneous methotrexate is significantly more effective than oral. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Which is more effective methotrexate or plaquenil Methotrexate or Plaquenil? DailyStrength, RA and Hydroxychloroquine How Effective is it for Rheumatoid. Plaquenil false positive Methotrexate was more effective than hydroxychloroquine in treating refractory lichen planopilaris. Further multi-center studies with larger sample sizes and longer follow-ups are warranted. Financial support and sponsorship This study was supported by Isfahan University of Medical Sciences. Conflicts of interest There are no conflicts of interest. Clinical efficacy and safety of methotrexate versus.. Is Injectable Methotrexate or Oral Methotrexate Better?. Combination Therapy for Rheumatoid Arthritis in the Era of Biologicals. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. Hi everyone! I'm a fairly new methotrexate and hydroxychloroquine user started both in mid-December of last year and am due to go on holiday in Florida on Saturday. There have been a number of coronavirus cases in Florida and two deaths there from the illness. Being on immunosuppressants I'm a little nervous to be travelling there. We compare the side effects and drug effectiveness of Plaquenil and Methotrexate. The study is created by eHealthMe based on reports of 385,604 people who take Plaquenil and Methotrexate, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Our original studies are referenced on 600+ peer-reviewed medical publications.