I am very underweight and do have chronic diarrhea, but gosh, this seems invasive as a first step in trying to figure out . Has anyone had chronic diarrhea/weight loss from Plaquenil? What tyoe of arthritis is plaquenil Ra and hydroxychloroquine Hydrox chloroquine Chloroquine phosphate for sale Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. I have been on Plaquenil and can tell you my diarrhea started within days of starting the med. My doctor warned me that diarrhea and weight loss were side effects. I said, "Well, I am usually very constipated and could stand to lose 10 pounds so this could be a good thing." haha. I am NOT constipated any more but have not lost any weight either. I can tell you, I will take the discomfort of diarrhea over the discomfort, bloatiness and hemorrhoids from constipation. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. My rheumatologist nor the GI doctor have suggested alternate treatments to see if it could be the problem. I know it can be a temporary side effect for some, but I've been on it for a year. Does plaquenil cause diarrhea Common and Rare Side Effects for Plaquenil Oral, Plaquenil, diarrhea and weight loss? Chloroquine resistant falciparum malaria What is hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Hydroxychloroquine Plaquenil. Plaquenil Uses, Dosage & Side Effects -. Aug 14, 2017 According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. Plaq did give me diarrhea, and there are OTC meds like Immodium AD and script meds like Hyoscyamine that can help there. Over time my tummy adjusted to Plaq. I did find that taking it with milk made my tummy troubles worse, but it is recommended to take it with food.