Chloroquine and immune complement activation

Discussion in 'Chloroquine' started by Penoplast, 22-Feb-2020.

  1. ravekeeper XenForo Moderator

    Chloroquine and immune complement activation


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    The activation of the classical pathway of complement by antibody coated sheep erythrocytes and aggregated IgG was blocked by chloroquine. Similarly, it prevented normal rabbit erythrocytes and zymosan from activating the the alternative pathway of complement. Recently, one of the review papers suggests the rational uses of chloroquine analogs counteract immune activation in HIV infection Savarino and Shytaj 2015. However, another retrospective review confronts the statement of ‘dampening of immune activation by the analog’ Chauhan and Tikoo 2015. Thus, if the analog‐based strategies pursue. Oct 01, 2018 Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver,spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma.

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    Chloroquine and immune complement activation

    Complement Pathways Types, Functions and Regulation - microbeonline, Targeting endosomal acidification by chloroquine analogs.

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  3. Complement activation is tightly regulated and designed to kill invading microbes while producing minimal “collateral damage” that could result in the destruction of host tissues. Complement proteins in the circulation are not activated until triggered by an encounter with a bacterial cell, a virus, an immune complex, damaged tissue or other substance not usually present in the body.

    • Complement Deficiencies Immune Deficiency Foundation.
    • Chloroquine - FDA prescribing information, side effects and uses.
    • Chloroquine and beyond exploring anti-rheumatic drugs to reduce immune..

    We evaluated chloroquine CQ as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38+ HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8. Complement activation is triggered by an antibody when it is bound to the antigen. It can also be triggered by some components of innate immunity. Thus the complement system works in both innate and acquired immunity. Complements are activated only during inflammatory reactions. Chloroquine is currently approved by the U. S. Food and Drug Administration FDA for the treatment of malaria and certain amoeba infections. 5 Researchers have evaluated whether chloroquine can reduce immune system hyperactivity also called immune activation as part of a strategy to treat or cure HIV infection.

     
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