She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Receptor tyrosine kinase dengue virus chloroquine Plaquenil and tb Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Keep away from children. Accidental exposure may cause death. If a child takes Plaquenil hydroxychloroquine by accident, get medical help right away. Use with care in children. Talk with the doctor. If you are 65 or older, use Plaquenil hydroxychloroquine with care. You could have more side effects. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil toxicity monitored with Plaquenil Hydroxychloroquine Sulfate, Plaquenil Indications, Side Effects, Warnings - Ra treatments plaquenilOct image plaquenil toxicity Patients with any of the aforementioned findings are considered “high risk” and should be monitored closely. 2011 Testing Guidelines. Since the initial screening and monitoring recommendations were published in 2002, there have been reports of retinal toxicity associated with the use of Plaquenil. New Plaquenil Guidelines -. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil - Uses, Side Effects, Interactions -. The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. With prolonged usage, metabolites in the drug accumulate in the retina. The drug remains in these parts even if the patients stopped taking the drugs. Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. Some doctors and eye care specialists haven’t checked Plaquenil patients regularly for toxic damage to the retina, the light-sensitive tissue at the back of the eye. At the recommended dose, Plaquenil retinal toxicity is rare. It might not always cause symptoms, especially in its early stages. Toxicity symptoms can include skin rashes.