In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Chloroquine phosphate site drugs.com Teva chloroquine side effects Plaquenil side effects cough Chloroquine eye toxicity Sjogren's Syndrome Support Group. Sjogren's syndrome is an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. It also associated with rheumatic disorders such as rheumatoid arthritis, and it is rheumatoid factor positive in 90 percent of cases. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. User Reviews for Plaquenil to treat Sjogren's Syndrome. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. How does plaquenil work for sjogren& 39 Treating Lupus with Anti-Malarial Drugs Johns Hopkins., Taking Plaquenil for Rheumatoid Arthritis Plaquenil side effects increased appetitiePlaquenil and immune system Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Plaquenil User Reviews for Sjogren's Syndrome at. Medications for Sjogren’s Syndrome NYU Langone Health. Sjogren’s syndrome can affect all moisture-producing glands and tissues in the body – not just the eyes and mouth – and cause a host of symptoms. Below is head-to-toe a look at over-the-counter and prescription treatment options, as well as some medical procedures, for this common autoimmune condition that affects nine times as many women. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial. The short answer is that nobody really knows how or why Plaquenil helps autoimmune diseases- they just know it does. It was discovered by accident - it's an anti-malarial drug, and doctors noticed that while being treated for malaria, patients with Rheumatoid autoimmune conditions had spontaneous improvement of symptoms.