Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil for chronic hives Non malarial uses of chloroquine Structure and Functional Differentiation of PfCRT Mutation in Chloroquine Resistance CQR in Plasmodium falciparum Malaria, Current Topics in Malaria, Alfonso J. Rodriguez-Morales, IntechOpen, DOI 10.5772/64659. Chloroquine is a 9-aminoquinoline that has been known since 1934. Specifically synthesised to be used as an antimalarial agent, chloroquine was subsequently shown to have immunomodulatory properties that have encouraged its application in the treatment of autoimmune diseases such as rheumatoid arthritis. Aug 27, 2018 Chloroquine a convoluted path from malaria to cancer treatment Chloroquine CHQ is a well-known antimalarial that has recently attracted considerable attention for its anti-neoplastic activites. Application of CHQ for cancer treatment is an example of drug re-purposing, a strategy for identifying new therapeutic indications for drugs that have initially been developed for different medical applications 7. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine malaria dna binding theory Defective DNA Repair as a Potential Mechanism for the Rapid., Effects of chloroquine on viral infections an old drug. Anyone developed kidney stone while on hydroxychloroquineChloroquine target protein Sion of this theory was presented by Ginsburg and colleagues, who suggested that chloroquine is directly toxic to the lysosome membrane i r. Another theory, proposed by Fitch '2, suggested that chloroquine acts by binding to ferri- protoporphyrin IX FP IX, forming a complex that is toxic to membranes. Chloroquine as Intercalator a Hypothesis Revived. Re-purposing Chloroquine for Glioblastoma Potential Merits.. Chloroquine Professional Patient Advice -. Chloroquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis; it is active against the asexual erythrocytic forms of Plasmodium and Entamoeba species. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malaria except for disease caused by chloroquine resistant Plasmodium falciparum. It is highly effective against erythrocytic forms of Plasmodium vivax, Plasmodium ovale and Plasmodium malariae, sensitive strains of Plasmodium falciparum and gametocytes of Plasmodium vivax. Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern.