Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Hydroxychloroquine poisoning What should you test for with hydroxychloroquine Can i take plaquenil and simvastatis Figure 2a and 2b this classic representation of Plaquenil toxicity is a preservation of the outer retinal layers subfoveally with perifoveal loss of the IS/OS junction on both sides of the fovea. Perifoveal IS/OS junction loss is associated with perifoveal outer retinal thinning, resulting in an ovoid appearance in the central retina, creating the flying saucer sign. Along with it comes thinning of the outer nuclear layer ONL, which is where the cell bodies of the photoreceptor cells reside. Vision loss from RP can also come from CME cystoid macular edema which is something to keep in mind for your RP patients. You can treat this with topical dorzolamide. Retinal detachment While MS could affect different retinal layers, outer retinal layer changes following acute ON without a previous history of MS have been evaluated in only a few studies. In one study, the GCIPL layer was evaluated, and its thinning, which represents permanent shrinkage or loss of retinal ganglion cells, was observed at 1 month Kupersmith et al. 2016. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil and thinning outer nuclear layer of retina Eye Exam May Aid Diagnosis of Frontotemporal Dementia, How to read OCTs 8 fundamental diseases - EyeGuru Plaquenil definitionCan plaquenil cause ear problemsSide effects of plaquenil mayo clinicHydroxychloroquine is it water pillHow does chloroquine work on malaria Conclusion HCQ toxicity resulted in significant outer retinal layer volumetric thinning compared with controls. Quantitative assessment of outer retinal parameters and EZ mapping on SD-OCT may become a useful biomarker to identify and monitor HCQ toxicity. Quantitative assessment of outer retinal layers and ellipsoid.. Photoreceptor outer nuclear layer thickness changes in optic.. Beware, thinning of the retina may indicate a.. Rats exposed to a 12 h lightdark cycle at 32 footcandles show thinning of the outer nuclear layer of the central superior retina midway between the ora ciliaris retinae and the optic nerve. From the normal 12 layers at 6 months of age, the cellularity shows progressive reduction to 10, 8, or 6 nuclei or less by 9, 18, and 24 months, respectively. The outer nuclear layer or layer of outer granules or external nuclear layer, is one of the layers of the vertebrate retina, the light-detecting portion of the eye. Like the inner nuclear layer, the outer nuclear layer contains several strata of oval nuclear bodies; they are of two kinds, viz. rod and cone granules, so named on account of. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1.