It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. I hate heart burn:( I take a PPI (proton pump inhibitor) essentially antacid in the morning that is supposed to last all day. I would ask your pharmacist first and see if it matters whether it is just a 'tums' or medication strength. I think if it keeps happening I’ll go talk to my pharmacist to see what they recommend. Has anyone else experienced heartburn while taking Plaquenil and if so what did you do to avoid or ease the heartburn? If they are not able to give you an answer your Family Dr or Rheumatoid will know. Fortunately the heartburn goes away after a few hours, but those few hours are very uncomfortable! Hydroxychloroquine loss of appetite Chloroquine and proguanil pregnancy Generic of hydroxychloroquine sulfate Plaquenil sore throat Antacids Major Hydroxychloroquine absorption may be reduced by antacids as has been observed with the structurally similar chloroquine. Administer hydroxychloroquine and antacids at least 4 hours apart. Plaquenil and heartburn. Hi everyone. I posted here a few days ago because I was about to start taking Plaquenil. So far it’s been okay, no major side effects. Except today I started having some heartburn after taking it. It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. Has anyone else. Give antacids and laxatives at least 4 h before or after hydroxychloroquine. Store at 15°–30° C 59°–86° F unless otherwise directed. Adverse Effects 1% CNS Fatigue, vertigo, headache, mood or mental changes, anxiety, retinopathy, blurred vision, difficulty focusing. GI Anorexia, nausea, vomiting, diarrhea, abdominal cramps, weight. But that's just the optimum way to take it, not the necessity. Sometimes what is suggested (no antacid for 4 hours) is not necessarily required if it means you can't or don't want to take your plaquenil anymore. the antacid will affect the absorption of the plaquenil and the amount your body can absorb. Hydroxychloroquine and antacids Hydroxychloroquine Side Effects, Dosage, Uses, and More, Plaquenil and heartburn rheumatoid Instructions for taking chloroquineChloroquine molecular weightChloroquine 750 mgPlaquenil interaction with alcoholPlaquenil and mastocytosis Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. HYDROXYCHLOROQUINE SULFATE. Hydroxychloroquine Side-effects, uses, time to work. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except. Hi Enjoy, You are right that only antacids react with plaquenil, not acid reducers, at least for the main ones that I checked on On which is one of our approved sites for linking in the forum, you can look up all your medications and the drug interaction listings are especially nice. Hi As far as I know the advice is to make sure that antacids and Plaquenil are taken at least 4 hours apart. If they are taken together - effectiveness decreases but 4 hours apart is OK.