Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Hydroxychloroquine myositis Hydroxychloroquine precautions Jan 05, 2020 Chloroquine was originally used as an anti-malarial therapeutic. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Its toxic effects on the retina are seen in the macula. Both medications are typically taken once per week, at the same time each week, throughout the duration of treatment. Hydroxychloroquine and chloroquine should always be taken for the entire length of time prescribed. Hydroxychloroquine and chloroquine are designed to be taken with food. Introduction. Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine vs hydroxychloroquine Chloroquine And Hydroxychloroquine Toxicity - StatPearls., What Is the Difference between Hydroxychloroquine and. Nifedipine and hydroxy chloroquine side effectsRaking tylenol after us8 g plaquenilCan hydroxychloroquine be taken with humira5 year plaquenil protocol Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Compare Chloroquine vs Plaquenil - Skip to full site navigation Compare Chloroquine vs Plaquenil -. Chloroquine And Hydroxychloroquine Toxicity - Abstract.. Chloroquine vs Hydroxychloroquine Comparison -. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. The 4-aminoquinoline drug hydroxychloroquine HCQ is reported to be as active as chloroquine CQ against falciparum malaria, and less toxic.