It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine monitoring ophthalmology Plaquenil alt levles My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? May 07, 2019 plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. How does hydroxychloroquine work for arthritis Treatments for Rheumatoid Arthritis, How is plaquenil hydroxychloroquine used to treat lupus? Hydroxychloroquine effects on kidneysPlaquenil associated hyperpigmentationHow long for plaquenil to take effect What next if plaquenil doesn't work? Support Forums Rheumatoid Arthritis New Topic Reply. for me methotreaxte and plaquenil does't work and i' intonate of sulfa so i am started embrel which states you have to have tried 2 of 3 meds and methotrexate is 1 of them. good luck What next if plaquenil doesn't work?. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Hydroxychloroquine Plaquenil - medications for.. Hydroxychloroquine does not work straight away. It may take 8 to 12 weeks for symptoms to start to improve. The full effect of treatment may take up to 26 weeks. Other medicines may be given to improve your symptoms while waiting for hydroxychloroquine to work. How is hydroxychloroquine taken? Hydroxychloroquine is taken by mouth in tablet form. Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone. Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. Less painful joints and fatigue. Always have gotten retina checked and have been good. Then I started getting debilitating migraines. I went off my meds one by one and the GENERIC was.