Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. What is in chloroquine Hydroxychloroquine tonic water Plaquenil and birth control Unusual bleeding with plaquenil Spin State of Chloroquine-Heme Complexes Formation of a Hemin Tetramer Adduct Article PDF Available in The Open Spectroscopy Journal 21 May 2008 with 78 Reads How we measure 'reads' Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Heme is a ferro-proto-porphyrin. Heme = Protoporphyrin IX ring + Iron Fe in center Protoporphyrin IX = porphyrin with attachment to 4 Methyl, 2 Propionyl and 2 Vinyl groups. Porphyrin = Cyclic Chloroquine possesses definite antirheumatic properties. Chloroquine has immuno-modulatory effects, suppressing the production/release of tumour necrosis factor and interleukin 6. Chloroquine inhibits trophozoite hemoglobin degradation through increasing vacuolar p H and inhibiting the activity of vacuolar phospholipase, vacuolar proteases, and heme polymerase. Heme chloroquine complex Chloroquine and hydroxychloroquine – Knowledge for medical students and., Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR activator Cheap aralen medication Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization. Along with the prevention of polymerization, the free heme accumulates in the food vacuole, exerting its toxic effects on the parasite. Chloroquine also functions as an anti-autoimmune therapy. Chloroquine - StatPearls - NCBI Bookshelf. Heme Synthesis and Defects Simplified Epomedicine. Chloroquine Pharmacology & Usage Details Medicine India. Polysaccharide iron complex Iferex 150, Ferrex 150, Niferex 150 is a prescription medication used to prevent or treat anemia. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed prior to taking this medication. Further studies using equilibrium dialysis determined that the affinity of chloroquine for ferric heme is high Kd = 3.5 nM at pH 7.4 and that the complex contains 2 mol heme to 1 mol chloroquine Chou et al. 1980. In support of this, Balasubramanian et al. 1984 have obtained spectral evidence that a chloroquine-heme complex forms/n situ inside chloroquine treated trophozoites. Sugioka et al. 1987 have also shown that a chloroquine-heme complex is more potent at promoting lipid peroxidation than free heine alone.