Effect of disease stage of progression of hydroxychloroquine retinopathy

Discussion in 'Chloroquine Drug' started by smproline, 27-Feb-2020.

  1. leXAndron User

    Effect of disease stage of progression of hydroxychloroquine retinopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Early detection of disease and cessation of hydroxychloroquine and chloroquine therapy are paramount, particularly before the occurrence of structural retinal pigment epithelium damage.2, 3 Cessation of the drug does not prevent the progression of retinopathy or reverse vision loss, but conservation of the retinal pigment epithelium is a. Chloroquine and/or hydroxychloroquine clear slowly from the body, so the full effects may not manifest for 3-6 months. Slow, continued deterioration of visual function may occur even after the drug is discontinued. Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol. 2014 Sep;13291105-12. 2. Marmor MF, Kellner U, Lai TY, Lyons JS, Mieler WF; American Academy of Ophthalmology.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Effect of disease stage of progression of hydroxychloroquine retinopathy

    Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA, Chloroquine and Hydroxychloroquine Toxicity Treatment.

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  7. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    • Hydroxychloroquine-Induced Retinal Toxicity - American..
    • Determine risk for hydroxychloroquine retinal toxicity..
    • Effect of Disease Stage on Progression of Hydroxychloroquine..

    Yusuf I, Sharma S, Luqmani R, Downes S. Hydroxychloroquine retinopathy. Eye 2017;8-45. 3. Pasadhika S, Fishman G. Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal structures. Eye 2010;0-46. 4. Marmor M, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol Hydroxychloroquine HCQ, brand name Plaquenil is commonly used for the long-term 2 management of a variety of chronic rheumatic diseases including systemic lupus erythematosus 3 and rheumatoid arthritis. Long-term use of antimalarial drugs including hydroxychloroquine and chloroquine can cause parafoveal retinal damage. In advanced stages, a ring scotoma a ring of vision loss surrounding the central area of normal vision can occur. Before 2014, the risk of hydroxychloroquine retinopathy was believed to be low.

     
  8. Fedu Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. How Does Methotrexate Treat Rheumatoid Arthritis? - WebMD Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Uses, Dosage & Side Effects -
     
  9. URRY New Member

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine - Wikipedia Retinal Screening for Hydroxychloroquine Plaquenil Toxicity Plaquenil Side Effects Common, Severe, Long Term -
     
  10. link-perm.ru New Member

    What to Do with Erosive, Inflammatory Osteoarthritis. EULAR Recommendations Absent specific treatment recommendations for erosive hand OA, Dr. Ramonda directed rheumatologists to the 2018 update of the European League Against Rheumatism EULAR recommendations for the management of hand OA. Overall, the recommendations emphasize the importance of controlling symptoms and reducing pain. Patients should be educated and trained in ergonomic.

    Plaquenil Archives - The Rheumatologist
     
  11. Mishelin Moderator

    Hydroxychloroquine toxicity - EyeWiki Jan 05, 2020 Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1

    Plaquenil Side Effects Common, Severe, Long Term -