Alternatively, we suggest using this opportunity to take a little break from work and read some of the interesting articles below. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Plaquenil easy bruising Ankylosing spondylitis hydroxychloroquine How does plaquenil affect lichen planus Plaquenil breastfeeding Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib. E Sunami, et al. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer. T Kometani, et al. Sensitivity to gefitinib Iressa, ZD1839 in non-small cell lung cancer cell lines. To investigate if the ability of pCQ to inhibit cancer cell migration and invasion in vitro translates into decreased metastasis in vivo, we used an experimental lung metastasis model of the 4T1 breast cancer. In this model, cancer cells are injected intravenously i.v. to colonize the lung and form lung metastasis. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Chloroquine lung cancer NCI Drug Dictionary - National Cancer Institute, The Autophagy Inhibitor Chloroquine Overcomes the Innate. ChloroquinDrug aralenChloroquine toxicity ecgChloroquine phosphate and alcohol Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after prolonged exposure to the drug. Repurposing Drugs 101 - Chloroquine & Lung Cancer. Polymeric chloroquine as an inhibitor of cancer cell.. Chloroquine enhances the cytotoxicity of topotecan by.. Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. Thus, chloroquine might very well be able to increase overall survival in small cell lung cancer by sensitizing cells resistant to chemotherapy and radiotherapy. The studies we included evaluated the treatment agents in various types of cancer with different etiologies and disease course. Different types of cancer may have some effect on the results of this meta-analysis. Two inhibitors chloroquine or hydroxychloroquine were evaluated in all cancer types. It may be different in different cancer types. Mice injected daily with chloroquine showed slower growth and less lung metastasis of subcutaneous melanoma xenografts. However, chloroquine did not suppress the invasion of cultured cancer cells into Matrigel, and lung colonization was not reduced by exposure of cancer cells to chloroquine prior to intravenous injection in mice.