Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Hydroxychloroquine interactions with famotidine Chloroquine cell death Plaquenil 200mg buy Homocysteine plaquenil My 7 year old daughter has been on Plaquenil for almost 2 years now. It is considered a disease modifying drug, but not an immunosuppressant. My daughter has never complained of fatigue or stiffness, but that might be because we caught the disease early on, and the medication has prevented it from the start. About Scleroderma Scleroderma is a connective tissue disease that involves changes in the skin, blood vessels, muscles, and internal is a type of autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Being tested for possible lupus or scleroderma. If that doesn’t bring me out of the flare, we will start talking Imuran in addition to Plaquenil. When I asked him if I should stay home from work and pull my kids out of school, he said it may be an overreaction, but since we don’t really know, my health comes first. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil forlimited sclera derma Morphea Localized Scleroderma - Dermatology Advisor, List of Scleroderma Medications 4 Compared - Hydroxychloroquine riskChloroquine crystal structureHydroxychloroquine and weight lossHydroxychloroquine prophylaxis Scleroderma is an autoimmune disease affecting the skin and other organs of the body, meaning that the body’s immune system is causing inflammation and other abnormalities in these tissues. The main finding in scleroderma is thickening and tightening of the skin and inflammation and scarring of many body parts. Scleroderma. Being tested for possible lupus or scleroderma? lupus. Anti-Malarial Medications - Scleroderma News. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Scleroderma is a multisystem disease with variable expression; thus any treatment plan must be holistic yet at the same time focus on the dominant organ disease. The goal of therapy is both to improve quality of life by minimizing specific organ involvement and subsequent life-threatening disease. Plaquenil has been extremely helpful to me and I hope that it will be for you as well. What ANA and antibody testing has been done so far? Detailed scleroderma antibody testing needs to be done if scleroderma is a possibility.