It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Side effects of plaquenil on the cornea Plaquenil bone marrow depression Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. Type of disease activity should be treated with hydroxychloroquine or chloroquine, unless these agents are contraindicated. The benefits of hydroxychloroquine or chloroquine in SLE are broad and include relief › Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil pediatric dose for sle Experts debate hydroxychloroquine dosing guidelines in lupus, Hydroxychloroquine in systemic lupus erythematosus SLE. Do you need to stop hydroxychloroquine before surgeryPlaquenil oral usesCan chloroquine cause anemia Systemic lupus erythematosus SLE is a multisystem autoimmune disorder characterized by widespread inflammation of the connective tissues and immune complex-mediated vasculitis. In children, it is fundamentally the same disease as in adults, with similar etiology, pathogenesis, clinical manifestations, and laboratory findings. Systemic Lupus Erythematosus in Children Pediatrics.. UpToDate. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Nov 25, 2019 Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. Apr 10, 2019 Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydroxychloroquine can be fatal, especially in children. Plaquenil overdose must be treated. The usual prescribed dose of hydroxychloroquine is 4–6/mg/kg/day. Additionally, hydroxychloroquine has an important role in cardiovascular protection, such as anti-platelet, anti-thrombotic, lipid-regulating, anti-hypertensive, hypoglycemic properties, which are important to consider in SLE patients 15.