Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. K63 ub after chloroquine Chloroquine huh7 Reducing plaquenil dosage Malaria hydroxychloroquine resistance Anybody else on Plaquenil Hydroxychloroquine and has had weird eye pain or dizziness neurological issues? What about side effects from being in the sun for a while? I've been on Plaquenil since last August and spent about 6 hours in the sun on Monday and I was super sick vomiting yesterday and today I'm still dizzy and my eyes are aching. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. I took plaquenil in 2005 and loved it. Best drug ever! Then suddenly I started to have eye pain in 2007 for no reason and even ear pain. I stopped it and it went away. My eye doc had no explanation and i had never had any signs of toxicity in my eyes. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Eye pain plaquenil Plaquenil Uses, Dosage & Side Effects -, Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine combination arimidexHydroxychloroquine false positive drug testAralen for malaria prophylaxisHydroxychloroquine and skin discoloration Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. Plaquenil and pain" Rheumatoid Arthritis Community.. Hydroxychloroquine and eye symptoms. The Risk of Retinal Toxicity with Plaquenil. Plaquenil lowers your immune system’s ability to cause inflammation. This can help control symptoms like rashes, skin and mouth sores and joint pain. Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time. I went to my rheumy appt and after 1hr 45 min later all had agreed it was the plaquenil. The strange thing is it had only affected the r eye. And yes i did have a baseline eye exam in oct before i started and then this one after experiencing the pain and pressure. So now i have to try the methotrexate inj. Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina.