Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Can chloroquine cause abortion Beaus lines plaquenil Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Keywords glioblastoma, chloroquine, autophagy, p53 Glioblastoma GBM is an aggressive astrocytic cell neoplasm and the most frequent adult brain tumor. 1 Current GBM treatment consists of a combination of surgery, radiation therapy, and chemotherapy and is mostly palliative in nature. The abnormal calcium flux is related to the expansion of the ER and higher calcium stores in the ER. Because of this, treatment with the ER sarco/ER Ca2+-ATPase pump inhibitor, thapsigargin, rescues the calcium influx defect in autophagy-deficient T cells. Therefore, autophagy regulates calcium mobilization in T lymphocytes through ER homeostasis. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Calcium autophagy chloroquine Calcium Homeostasis and ER Stress in Control of Autophagy., Chloroquine-induced autophagic vacuole accumulation and. Treatment of cerebral malaria chloroquine These data link lysosomal calcium signalling to both calcineurin regulation and autophagy induction and identify the lysosome as a hub for the signalling pathways that regulate cellular homeostasis. Lysosomal calcium signalling regulates autophagy through.. Frontiers Autophagy, a Novel Pathway to Regulate Calcium.. Chloroquine analogues in drug discovery new directions of.. In studying autophagy, small molecules such as bafilomycin and chloroquine are commonly used inhibitors, and it is known that the ability of these compounds to neutralize lysosomal pH impairs substrate degradation and disrupts autophagosome-lysosome fusion 30,31. Jan 27, 2010 Keywords glioblastoma, chloroquine, autophagy, p53 Glioblastoma GBM is an aggressive astrocytic cell neoplasm and the most frequent adult brain tumor. 1 Current GBM treatment consists of a combination of surgery, radiation therapy, and chemotherapy and is mostly palliative in nature. The protective effects of Torin 1 and C1 can be blocked by autophagy inhibitors like chloroquine CQ or by knocking down autophagy-related genes TFEB and ATG5.