Chloroquine inhibits autophagy in host tissues

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  1. standev Well-Known Member

    Chloroquine inhibits autophagy in host tissues


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    As autophagy is highly stimulated during Acanthamoeba encystation, and chloroquine inhibits autophagy, this led us to speculate that chloroquine could possess a therapeutic role in the treatment of Acanthamoeba by blocking the processes in the autophagic pathway. Jun 15, 2014 Chloroquine, an anti-malarial drug, inhibits autophagy by preventing degradation of autolysosomes. Moreover, chloroquine derivatives, such as HCQ, in combination with anti-neoplastic chemotherapeutic drugs or radiotherapy treatments inhibit multiple cancer cell types 32, 33. Cancer Therapy Preclinical Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ERþ Breast Cancer Katherine L. Cook 1, Anni W€arri, David R. Soto-Pantoja2, Pamela AG.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine inhibits autophagy in host tissues

    Hexokinase II inhibitor, 3-BrPA induced autophagy by., Hydroxychloroquine inhibits autophagy. - PubMed Central PMC

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  6. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4.

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    Chloroquine binds to the DNA and RNA polymerase and inhibits it. It interferes with nucleoprotein synthesis and causes cell damage. It also alters the cellular PH and acid-base balance causing an inhibitory effect on the organism’s growth and replication. It also inhibits autophagy. The antimalarial drug chloroquine CQ disrupts autophagy by inhibiting the acidification of the lysosomes that fuse with the autophagosomes, thereby preventing the degradation of metabolic stress products and inducing apoptosis. Chloroquine-mediated inhibition of autophagy has been demonstrated in melanoma. Chloroquine has a very high volume of distribution, as it diffuses into the body's adipose tissue. Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times.

     
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  9. mouse2004 XenForo Moderator

    AZATHIOPRINE Drug BNF content published by NICE The enzyme thiopurine methyltransferase TPMT metabolises thiopurine drugs azathioprine, mercaptopurine, tioguanine; the risk of myelosuppression is increased in patients with reduced activity of the enzyme, particularly for the few individuals in whom TPMT activity is undetectable.

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  10. Energ1zer Moderator

    Malarial Hemozoin From target to tool Hemozoin is involved in several aspects of the pathology of the disease as well as in important processes such as the immunogenicity elicited. It is known that the once best antimalarial drug, chloroquine, exerted its effect through interference with the process of hemozoin formation.

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