Why is p falciparum resistance to chloroquine

Discussion in 'Canadian Pharmacies Online' started by kompage, 22-Feb-2020.

  1. JORA XenForo Moderator

    Why is p falciparum resistance to chloroquine


    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s.

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    Abstract. The development of chloroquine as an antimalarial drug and the subsequent evolution of drug-resistant Plasmodium strains had major impacts on global public health in the 20th century. In P. falciparum the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite’s. David C. Warhurst, Jonathan C. P. Steele, Ipemida S. Adagu, John C. Craig, Christopher Cullander, Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties, Journal of Antimicrobial Chemotherapy, Volume 52, Issue 2, August 2003, Pages 188–193. From the 1940s-1990s, chloroquine was the mainstay of malaria therapy worldwide. Selection of P.falciparum-resistant isolates was first reported in Southeast Asia Thai-Cambodian border and South.

    Nowadays, other drugs, and notably ones containing artemisinin-based compounds, are preferentially used to treat uncomplicated malaria and especially in areas where chloroquine resistance is known to occur. Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America.

    Why is p falciparum resistance to chloroquine

    Evolution of Plasmodium falciparum drug resistance., Hydroxychloroquine is much less active than chloroquine.

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  5. Development of Chloroquine Resistance in Plasmodium falciparum. Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug.

    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.
    • Chloroquine Resistance in Malaria - ResearchGate.
    • On the Mechanism of Chloroquine Resistance in Plasmodium..

    Conclusion P. falciparum parasites with genotypic resistance to chloroquine have persisted in the population after more than a decade since the change of policy in Uganda. The P. falciparum chloroquine-resistance transporter PfCRT In 2000 a report by David Fidock and colleagues associated chloroquine resistance with mutations to the gene for a digestive vacuole transmembrane protein, pfcrt. PfCRT is a member of the drug/metabolite transporter superfamily. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s.

     
  6. Rizarudo Well-Known Member

    In the US, Hydroxychloroquine (hydroxychloroquine systemic) is a member of the following drug classes: antimalarial quinolines, antirheumatics and is used to treat Dermatomyositis, Lyme Disease - Arthritis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus and Undifferentiated Connective Tissue Disease. Hydroxychloroquine Side Effects, Dosage, Uses, and More HYDROXYCHLOROQUINE - Low Country Rheumatology Hydroxychloroquine - brand name list from
     
  7. guiness Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. Plaquenil hydroxychloroquine sulfate dose, indications. Methotrexate and plaquenil - Managing the Medicine Cabinet
     
  8. 122 User

    SD-OCT as screening test for hydroxychloroquine. A PubMed search with “flying saucer” as keyword only produced 2 articles.4, 5 In 25 patients treated with HCQ, Chen et al. 4 found toxicity in 5 20%, 2 patients with advanced toxicity and a further 3 with early toxicity, or exhibiting the flying saucer sign 12%.

    Compare Plaquenil vs Chloroquine -