Chloroquine mode of mechanism action

Discussion in 'Canadian Pharmacies Online' started by Makc72ru, 24-Feb-2020.

  1. DeV-87 New Member

    Chloroquine mode of mechanism action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubated cultured parasites with subinhibitory doses of 3Hchloroquine and 3H quinidine. These 3Hquinoline compounds became associated with hemozoin. Mechanism of action Chloroquine basic concentrates in parasite food vacuole acidic. Prevent heme polymerization into hemozoin causing heme accumulation toxic to parasite. Drug complex with heme disrupt cell membrane function. Other mechanism include intercalating of parasite DNA, DNA synthesis inhibition. 7.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine mode of mechanism action

    Mechanism of action of hydroxychloroquine as an antirheumatic., On the molecular mechanism of chloroquine's antimalarial action PNAS

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  7. The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology.

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    Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine was granted FDA Approval on 31 October 1949. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

     
  8. Wolf$ Well-Known Member

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  9. shane XenForo Moderator

    Joint damage worries and aching hands are no fun, and if you’re experiencing those kinds of problems because of rheumatoid arthritis you may have options that can help you feel better. RA And Methotrexate Methotrexate vs Plaquenil Comparison - Arthritis Which would you pick and why? - Plaquenil or.
     
  10. GGGIORGI Well-Known Member

    Treatment Lyme Disease CDC Dec 17, 2019 This condition is known as “Post-treatment Lyme Disease Syndrome” PTLDS, although it is often called “chronic Lyme disease.” For details on research into “chronic Lyme disease” and long-term treatment trials sponsored by NIH, visit the visit the National Institutes of Health Lyme Disease web site external icon.

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