Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Does hydroxychloroquine affect immune system Long-term progression of hydroxychloroquine retinopathy off the drug Hydroxychloroquine plaquenil mechanism of action Chloroquine causes a toxic myopathy but also produces a toxic neuropathy. Chloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritis, systemic lupus erythematosus, and other dermatological diseases. The clinical features of chloroquine-induced neuropathy are those of symmetrical sensorimotor polyneuropathy. Chloroquine is FDA-approved for the treatment and prophylaxis of uncomplicated malaria in countries where chloroquine-sensitive malaria certain strains of P. falciparum, P. ovale, P. vivax, and P. malariae is present. Neuropathy can include seizures, paranoia, and hallucinations. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine and neuropathy Chloroquine - Wikipedia, Chloroquine - StatPearls - NCBI Bookshelf Plaquenil and eggsBuy aralen prescribing Lupus and Nerve Damage. Everyone suffers from the occasional tingling or numbness in their hands or feet, usually when limbs "fall asleep.". But, when you're living with lupus, numbness or tingling in your hands or feet may not be minor, passing symptoms. They can signal a condition called peripheral neuropathy, or nerve damage. Lupus and Nerve Damage. Chloroquine and Hydroxychloroquine Toxicity Practice.. Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs. Diabetes and alcoholism are the most common etiologies of peripheral neuropathy in adults living in developed countries. The primary worldwide cause of treatable neuropathy is leprosy.1 Neuropathies associated with human immunodeficiency virus HIV infection account for an increasing number of cases. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone. Neuropathy dominates my symptom set, with fatigue and oral dryness right up there. Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation.