Category: Antiprotozoal— antirheumatic (disease-modifying)— lupus erythematosus suppressant— antihypercalcemic— polymorphous light eruption suppressant— porphyria cutanea tarda suppressant— Indications Note: Bracketed information in the Indications section refers to uses that are not included in U. Also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. falciparum and the other 3 malarial species; however, chloroquine-resistant P. Unaccepted Hydroxychloroquine does not prevent relapses in patients with P. ovale malaria since it is not effective against exo-erythrocytic forms of the parasite. Pharmacology of chloroquine Withdrawal symptoms of plaquenil Hydroxychloroquine vision side effects Antiboptics and plaquenil Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. A diagnostic tool that aids in the detection of visual disturbances caused by such changes in the macula is called the Amsler Grid. In this test, a person looks with each eye separately at the small dot in the center of the grid. Patients with macular disease may see wavy lines or some lines may be missing. Causes Plaquenil-induced toxicity usually will not occur before five years of taking the drug. you can use the Amsler Grid at home to help detect early problems. [ It may be used in addition to nonsteroidal anti-inflammatory agents.] Lupus erythematosus, discoid (treatment) or Lupus erythematosus, systemic (treatment)—Hydroxychloroquine is indicated as a suppressant for chronic discoid and systemic lupus erythematosus . falciparum , originally seen only in Southeast Asia and South America, are now documented in all malarious areas except Central America west of the Canal Zone, the Middle East, and the Caribbean. Chloroquine is still the drug of choice for the treatment of susceptible strains of P. Plaquenil grid Hydroxychloroquine toxicity - EyeWiki, Epiretinal Membrane Symptoms, Causes, Treatments Plaquenil skin rash symptoms You can also monitor yourself between visits with a special grid called an Amsler grid, which can be obtained through your ophthalmologist. If your ophthalmologist does find some Plaquenil deposits, s/he will simply request that you stop taking the medication, and you may follow up with your rheumatologist about another advised method of treatment. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center. Protecting your eyesight when taking Plaquenil Lupus Foundation of.. PowerPoint. Update on Plaquenil Testing. I was glad of this cause, like jennifer, when I started plaquenil last June I'd only had brief advice, and I felt maybe more was needed than your basic eye test annually + more frequent amsler grid tests. Plaquenil was first developed for Milaria. It has been around for a very long time. I have only heard of one person who had eye problems, and she had been taking it for several years. Most of the people that we know have not had side effects from the plaquenil. I hope you feel better soon. However, it is important to monitor your eyes for side effects that might indicate the need to stop taking Plaquenil. The Amsler grid chart below should be checked at least once a week testing each eye separately, using glasses if needed.