Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. What is a potential adverse effect of hydroxychloroquine plaquenil Hydroxychloroquine method of action arthritis Plaquenil turns hair white H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Mar 10, 2017 Spectral-domain OCT SD-OCT is a widely available technology that permits objective, structural evaluation of the macula in patients at risk of HCQ retinopathy. SD-OCT images may have important implications to use as an early indicator of retinal toxicity without any visible signs of hydroxychloroquine retinopathy. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Hydroxychloroquine retinopathy oct Bull's-eye maculopathy due to hydroxychloroquine toxicity, Hydroxychloroquine retinopathy Eye Plaquenil 200 mg film-coated tabletsChloroquine tat creHydroxychloroquine side effects mayo clinicLong term chloroquine prophylaxisChloroquine nursing implications Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as. Hydroxychloroquine retinopathy A review of imaging - NCBI. Effect of Hydroxychloroquine on the Retinal Layers A.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Thirty eyes with HCQ retinopathy were followed with SD-OCT after drug cessation. Findings before disruption of the parafoveal EZ included parafoveal outer nuclear layer ONL thinning, disruption of the parafoveal interdigitation zone, and reduced reflectivity of the parafoveal EZ. Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. Oct 21, 2010 The use of hydroxychloroquine HCQ, an antimalarial drug utilized for a range of rheumatologic and dermatologic diseases, is associated with a low incidence of retinopathy 0.5% when used at recommended doses 6.5 mg/kg per day. 1 It has largely replaced chloroquine because of decreased ocular toxicity at high dosages, 2 but can still lead to potentially irreversible visual loss.