It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil dark spots Chloroquine mechanism of action iodine Plaquenil is in a class of medicines known as antimalarials. It's a less toxic version of the older antimalarials, including quinine and chloroquine. The drug is also in a group of biologic medicines known as disease-modifying anti-rheumatic drugs DMARDs, because of its effects on autoimmune illnesses. Both malaria and diabetes are more common in the developing world, and are major public health challenges. A direct relationship between these 2 conditions has not been evaluated. This review article assessed the literature guaging the relationship between these two conditions, and suggests a pragmatic approach to management. Dec 13, 2018 Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, the parasites that cause malaria are resistant to chloroquine, and the drug is no longer an effective treatment. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Chloroquine diabetes Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, PDF Malaria and diabetes Hydroxychloroquine and chloroquine comparisonInteraction between plaquenil and augmentin ibuprofenPlaquenil and breastfeeding Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. Hydroxychloroquine - Wikipedia. Malaria - Diagnosis and treatment - Mayo Clinic. Hydroxychloroquine Uses, Dosage & Side Effects -. Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease The broad spectrum antiviral effects of chloroquine deserve particular attention in a time in which the world is threatened by the possibility of a new influenza pandemic, and the availability of effective drugs would be fundamental during evaluation of an effective vaccine. Glucose-6-phosphate dehydrogenase G6PD is an enzyme in the pentose phosphate pathway see image, also known as the HMP shunt pathway. G6PD converts glucose-6-phosphate into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of this metabolic pathway that supplies reducing energy to cells by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide.