B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plaquenil maculopathy dose Causes for plaquenil to stop working Plaquenil toxicity bull's eye maculopathy American academy of ophthalmology plaquenil screening guidelines Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Plaquenil is supposed to help with hair loss, not contribute to it. I would also suggest giving it some more time especially since the side effects of plaquenil are supposed to lessen after a few months of use. Drug-induced nail disease is diagnosed when a medication affects nail growth or structure. Drugs may cause Changes to the shape of the nail nail deformity Changes in the texture or composition of the nail nail dystrophy Abnormality of the tissues around the nail paronychia Pigmentation of the nail plate. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Common and Rare Side Effects for Plaquenil Oral, Hair loss and Plaquenil? DailyStrength Plaquenil not workingChloroquine mechanism of action iodineHydroxychloroquine sle mechanism This means many people taking Plaquenil for RA are taking a dose of 400mg a day or higher. Pigment deposits in the retina can cause vision changes, according to Steven Ofner, M. D. of Eugene Oregon Eye Care. Signs of retinal damage include blurry or distorted vision, flashes of light or floaters, or loss of night vision. Long-Term Side Effects of Plaquenil for Rheumatoid.. Drug-induced nail disease DermNet NZ. Tips for Dry and Brittle Nails. Nail changes are common in association with SLE, affecting up to 31% of patients.7 The most prevalent findings are prominent nail fold capillaries, vascular infarction, and red lunulae.3 Pincer nails have only been described once in association with SLE; Majeski et al.3 reported pincer nails in a patient with a 4-month history of SLE, who also. Nail changes? Has anyone noticed changes to their nails? I have horizontal ridges on my thumbs and also my toes. comment. share. save hide report. Plaquenil or something else to prevent their Sjogren's from getting worse--or has decided against it. I was diagnosed last year. I'm in my 50s and an anti-inflammatory diet has helped me a lot. The procedure involves Numbing the skin with an injectable anesthetic. Sampling a small piece of skin by using a flexible razor blade, a scalpel, or a tiny cookie cutter called a "punch biopsy". If a punch biopsy is taken, a stitch suture or 2 may be placed and will need to be removed 6–14 days later.