If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. It can be brief or as detailed as you desire to describe your experience. I used plaquenil for some time on its own, then added in MTX before changing over to leflunomide. Aralen 250 mg Hydroxychloroquine plaquenil price For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Plaquenil hydroxychloroquine "I have been on this medication for approximately 8 years. Before I started this medicine I was in terrible shape. With Sjogren's syndrome as my primary autoimmune disease and rheumatoid arthritis as my secondary autoimmune disease I was in terrible persistent pain. Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. I would have stayed on MTX if it worked for me, but it didn’t. I didn’t drop plaquenil until I had been on a biologic for about six months. Plaquenil and methotrexate for sjogren's syndrome Methotrexate opinions - Symptoms and Medical Treatments - Sjogren's., Hydroxychloroquine User Reviews for Sjogren's Syndrome at. Can you take doxe-pin hcl and hydroxychloroquine 200 mg toHydroxychloroquine vs methotrexate for rheumatoid arthritis Mar 18, 2012 Plaquenil won't directly affect dry-eye, but it can slow the progress of the disease and, therefore, hopefully slow down the rate at which your body is attacking your tear glands in other words, it might not make things better, but it may keep them from getting worse. Plaquenil has been a lifesaver for me in so many ways. Sjogren's diagnosis - prescribed Plaquenil?. Hydroxychloroquine User Reviews for Sjogren's Syndrome at. Plaquenil side effect, loss of appetite - Sjogren's Syndrome.. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. NSAIDS - or non steroidal anti inflammatory drugs such as Motrin, are often very irritating to the stomach and intestines. Other medications frequently used in treating Sjogren's Syndrome such as Plaquenil and Methotrexate may cause stomach upset. Does anyone use methotrexate just for their Sjogrens symptoms? If so, would you share a comment on the experience you have had with methotrexate; & the length of time on the medication, benefits noted, and side effects. Sjogren's Syndrome Support. Methotrexate opinions. Symptoms and Medical Treatments _Lisa_D. I used plaquenil for some.