Map of chloroquine resistant malaria

Discussion in 'Canadian Drugs' started by holo, 09-Mar-2020.

  1. splashx User

    Map of chloroquine resistant malaria


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. DRUG RESISTANT MALARIA Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Map of chloroquine resistant malaria

    Chloroquine - FDA prescribing information, side effects., Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings.

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  7. Malaria remains one of the most devastating infectious diseases with approximately 228 million infections and 405,000 deaths in 2018 – primarily children under the age of five in sub-Saharan Africa. Plasmodium falciparum, the deadliest form of the malaria parasite, is responsible for the vast majority of the mortality and morbidity associated with malaria infection.

    • Malaria Drug Resistance Worldwide Antimalarial..
    • DRUG RESISTANT MALARIA CURRENT STATUS.
    • On the Mechanism of Chloroquine Resistance in Plasmodium falciparum.

    Abstract. Plasmodium falciparum chloroquine resistance CQR transporter point mutation PfCRT 76T is known to be the key determinant of CQR. Molecular detection of PfCRT 76T in field samples may be used for the surveillance of CQR in malaria-endemic countries. Chloroquine resistance is widespread. Chloroquine should not be used for treatment of P. falciparum infections from areas of chloroquine resistance or malaria occurring in patients where chloroquine prophylaxis has failed. Patients infected with a resistant strains of plasmodia should be treated with another antimalarial drug. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s.

     
  8. barrrs New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Hydroxychloroquine - Safe In Breastfeeding Tizanidine Oral Route Before Using - Mayo Clinic UpToDate
     
  9. GrandSEO User

    DailyMed - PLAQUENIL- hydroxychloroquine sulfate tablet Jan 03, 2020 Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days.

    Hydroxychloroquine - Wikipedia
     
  10. YO-ZURI Well-Known Member

    Rheumatoid Arthritis Treatment Options Johns Hopkins. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system.

    Sulfasalazine and Hydroxychloroquine • Versus Arthritis.