This condition is a common side effect of chemotherapy. Severe myelosuppression, called myeloablation, can be fatal. The body’s bone marrow produces three types of cells: white blood cells, red blood cells, and platelets. Generic plaquenil coupon Hydroxychloroquine medical definition Bone marrow suppression refers to a decrease in the ability of the bone marrow to manufacture cells, and is common with chemotherapy. In addition to eliminating cancer cells, chemotherapy drugs eliminate normal cells that divide rapidly, such as those in the bone marrow that form the different types of blood cells. PLAQUENIL hydroxychloroquine sulfate tablets is indicated for the treatment of rheumatoid arthritis, and discoid and systemic lupus erythematosus, in patients who have not responded satisfactorily to drugs with less potential for serious side effects. Bone marrow suppression is a common dose-limiting toxicity for most immunosuppressive drugs, apart from hydroxychloroquine and the glucocorticoids. The recommendations for monitoring are largely based on expert consensus and often differ slightly. 1, 2 Table 1 has a suggested frequency of monitoring for patients who have been stable on maintenance doses of immunosuppressive drugs. A decrease in all three types of blood cells is referred to as pancytopenia. It can cause an oxygen shortage and other immune issues. Myelosuppression can decrease some or all of these. Hydroxychloroquine bone marrow suppression Hydroxychloroquine Causes Severe Vacuolar Myopathy in a., Plaquenil Hydroxychloroquine Sulfate - Sanofi What drug is comparable to plaquenil Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells. Rare but potentially serious eye toxicity can occur. This toxicity affects a part of the eye called the retina and can lead to color blindness and even loss of vision. An. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Long-term management of patients taking immunosuppressive drugs. Hydroxychloroquine Disease Interactions -. Hydroxychloroquine HCQ is a disease-modifying anti-rheumatic drug DMARD typically used for the treatment of various rheumatic and dermatologic diseases. Three studies of HCQ in OA, including one abstract and one letter, are available and use a wide variety of outcome measures in small patient populations. Methods/Design. OA TREAT is an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial. A total of 510 subjects with inflammatory and erosive hand OA, according to the classification criteria of the American College of Rheumatology ACR, with recent X-ray will be recruited across outpatient sites, hospitals and universities in Germany. Given this presentation, severe bone marrow suppression accompanying pulmonary infection and hemorrhage of the digestive tract associated with MTX and LEF combination therapy was diagnosed. Combination therapy of MTX and LEF was stopped, and celecoxib was also suspended because of possible liver toxicity.