Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil hyponatremia Does hydroxychloroquine make you bone pain Dec 10, 2018 Autophagy following chloroquine diphosphate treatment The present study design of the whole investigation is depicted in Fig. 1. The LC3-II expression level was significantly reduced in the control group, compared with the group treated with 25 or 100 µ M chloroquine diphosphate P0.05. Chloroquine CQ, which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells. Inhibition of autophagy using chloroquine CQ together with LUT treatment in MET4 cells decreased viability significantly more than addition of LUT alone. Cutaneous SCC is a very common cancer in the Caucasian population 38 and although most SCCs can be cured, a subset of patients, like organ transplant recipients OTR develop advanced SCC with a high risk of metastasis 39. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine diphosphate autophagy Chloroquine phosphate autophagy inhibitor, Autophagy inhibitor chloroquine induces apoptosis of cholangiocarcinoma. Hydroxychloroquine sulfate solubilityHydroxychloroquine plaquenil and pregnancy Mar 03, 2014 While in combination with the pre-treatment of chloroquine CQ, a inhibitor of autophagy, the inhibition of 5-FU to the proliferation and viability of GBC cells was potentiated. Furthermore, 5-FU treatment resulted in a general increase of the apoptotic rate and G0/G1 arrest of GBC cells, and the effect was potentiated by CQ pre-treatment. Suppression of autophagy by chloroquine sensitizes 5.. Autophagy Inhibitor Chloroquine Enhanced the Cell Death.. Chloroquine diphosphate Autophagy Inhibitor MedChemExpress. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years. Oct 01, 2014 Chloroquine is an antimalarial drug that has been used in humans for many years 1. In recent years, Chloroquine has been shown to inhibit autophagy and induce apoptosis in malignant cells and thus has been tested in various experimental model systems 2 and in human clinical trials 3, 4. Product name Chloroquine diphosphate, apoptosis and autophagy inhibitor. Description Antimalarial; apoptosis and autophagy inhibitor. Biological description Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro.