Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Saltwater fish chloroquine compatible with metroplex Hydroxychloroquine arthritis mechanism Chloroquine and hydroxychloroquine increase pH within intracellular vacuoles and alter processes such as protein degradation by acidic hydrolases in the lysosome, assembly of macromolecules in the endosomes, and posttranslation modification of proteins in the Golgi apparatus. Systemic lupus erythematosus SLE, also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary between people and may be mild to severe. Common symptoms include painful and swollen joints, fever. Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus. Arthritis Rheum 2006; 84. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil lupus mechanism Hydroxychloroquine Plaquenil Side Effects & Dosage for., Systemic lupus erythematosus - Wikipedia Hydroxychloroquine intracellular ph Medscape - Indication-specific dosing for Plaquenil hydroxychloroquine sulfate, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Plaquenil hydroxychloroquine sulfate dosing, indications.. UpToDate. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine in systemic lupus erythematosus SLE Ponticelli C 1 and Moroni G 2 1 MD, Senior Consultant Nephrological Unit, Humanitas Clinical and Research Center, Hydroxychloroquine is useful for the dermatologic, musculoskeletal and mild constitutional manifestations of lupus. Its mechanism of action is uncertain but it may work by interfering with lysosomal function and thus impairing phagocytic activity.