Why chloroquine is given in loading dose

Discussion in 'Canada Pharmacy Online' started by n1kon, 25-Feb-2020.

  1. gaik911 Guest

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Indeed, Chloroquine is a potent blocker of autophagy and has been demonstrated in a lab setting to dramatically enhance tumor response to radiotherapy, chemotherapy and even anti-hormonal therapy. This is why Chloroquine has become part of many clinical trials, in combination with chemotherapy and other form of cancer treatments. The loading dose is administered in order to achieve a therapeutic amount in the body more rapidly than would occur only by accumulation of the repeated smaller doses. The smaller doses D which are given after D* are called “maintenance doses”. Anyone heard anything about this, or have speculation on if that would be effective at the more tolerable malaria prophylaxis dose or the accelerated loading dose maybe. TI is not great on Chloroquine, and if someone is dying of SARS-CoV-2 you don't care about side effects too much and push it up to the limit, but would be a real concern for.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Vancomycin loading dose - the pharmacokinetics to consider., Loading dose definition CME at Pharmacology Corner

  2. I c hydroxychloroquine hsdd
  3. Where complete treatment of severe malaria is not possible but injections are available, give adults and children a single intramuscular dose of artesunate, and refer to an appropriate facility for further care. Where intramuscular artesunate is not available use intramuscular artemether or, if that is not available, use intramuscular quinine.

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    To avoid nausea and vomiting chloroquine should be administered after meals. If part or all of a dose is vomited, the same amount must immediately be readministered. Adults, including pregnant women, and children Total dose 25 mg/kg given over 3 days. Day 1 10 mg/kg, followed by 5 mg/kg 6-8 hours later. Days 2 and 3 5 mg/kg in a single dose. What I’m wondering is if there is any relationship with increasing the loading dose and the time taken to reach the steady state. For example, if a greater loading dose was given for a particular drug, would this decrease the time taken to reach the steady state compared to smaller loading dose? Thank you very much in advance. Kind Regards, Sarah Some medicines need to be given at high initial doses loading doses at the start of treatment, before being reduced to a lower, maintenance dose. Reasons vary for the need for loading doses. In some patients the therapeutic level is needed very quickly—for example, phenytoin to stabilise a patient after a seizure.

     
  4. Jean New Member

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Oral Route Description and Brand Names - Mayo Clinic Hydroxychloroquine - Side Effects, Dosage, Interactions. Hydroxychloroquine Oral Uses, Side Effects, Interactions.
     
  5. Vanila Well-Known Member

    Hydroxychloroquine MedlinePlus Drug Information If you are taking hydroxychloroquine for a long period of time, your doctor will recommend frequent eye exams. It is very important that you keep these appointments. Hydroxychloroquine can cause serious vision problems. If you experience any changes in vision, stop taking hydroxychloroquine and call your doctor immediately.

    Can Hydroxychloroquine cause Hair Loss? - Page 3