Porphyria Cutanea Tarda (PCT) is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin (photosensitivity). Affected skin is fragile and may peel or blister after minor trauma. PCT is essentially an acquired disease, but some individuals have a genetic (autosomal dominant) deficiency of UROD that contributes to development of PCT. Autoimmune plaquenil Hydroxychloroquine hyperpigmentation treatment Dec 20, 2019 Kordac V, Semradova M. Treatment of porphyria cutanea tarda with chloroquine. Br J Dermatol. 1974 Jan. 90195-100. Battle AM, Stella AM, De Kaminsky AR, Kaminsky C, Mariano HG. Two cases of infantile porphyria cutanea tarda successful treatment with oral S-adenosyl-L-methionine and low-dose oral chloroquine. Aug 16, 2017 Treatment of porphyria cutanea tarda can include Regular blood removal phlebotomies to reduce the amount of iron in the liver. Low doses of the antimalarial drug chloroquine or hydroxychloroquine. Avoidance of triggers. Treatment of any underlying condition such as HIV or hepatitis C. The skin lesions of pseudoporphyria closely resemble those seen in cutaneous forms of porphyria including porphyria cutanea tarda. Pseudoporphyria can occur at any age. Women are affected more often than men. Most individuals with the inherited enzyme deficiency remain latent and never have symptoms. These individuals are referred to as having "familial PCT". Treatment of porphyria cutanea tarda with chloroquine Porphyria - Diagnosis and treatment - Mayo Clinic, How are acute porphyria and porphyria cutanea tarda treated? Malaria proguanil and chloroquineEffectiveness of chloroquine in malariaChloroquine effect on gametocytesWhat is chloroquine In 59 patients showing clear clinical and biochemical signs of porphyria cutanea tarda PCT, we tested 3 different modes of therapy 20 patients received combined treatment with repeated bleeding and chloroquine, 24 patients were exclusively treated with oral chloroquine in low doses, and 15 patients underwent repeated phlebotomy only. Results of treatment of porphyria cutanea tarda with.. Porphyria Cutanea Tarda - NORD National Organization for.. The Therapeutic Effect of Chloroquine Hepatic Recovery in.. Porphyria Cutanea Tarda PCT is the most common of the Porphyrias and results from a deficiency of the enzyme uroporphyrinogen decarboxylase UROD. Porphyria Cutanea Tarda PCT is a rare disorder characterized by painful, blistering skin lesions that develop on sun-exposed skin photosensitivity. Porphyria cutanea tarda PCT is common in Ethiopia and invariably affects the liver. Treatment by abstension from alcohol and avoidance of direct sunlight often failed to achieve lasting improvement. Because there is a strong association between Hepatitis C virus infection and porphyria cutanea tarda it is vital that the Hepatitis C virus infection is also treated if it shows that you have this medical condition. Porphyria cutanea tarda is normally treated first and then Hepatitis C virus infection is treated.